Personalized Glioblastoma Drug Testing

Neuron D’s patented platform, developed in Germany, models key features of glioblastoma to help doctors understand how a patient’s tumor may respond to treatment.

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Every tumor is different

One size does not fit all! That’s why treatments don’t affect your tumor the same way.

Physicians need to determine the best treatment but this takes time for a disease that requires immediate action.

Our mission is to support them with personalized laboratory data, using your own tumor replica grown in our 3D Patient Avatar technology.

In less than a month, we can advise on which drugs or their combinations could be effective on your tumor.

How does 3D Glioblastoma Avatar works? 

For patients and families

  1. Clinician performs a biopsy or surgery as part of the normal care

  2. With the patient consent, a small tissue sample is sent to our laboratory.

  3. We grow the tumor cells with our 3D Glioblastoma Patient Avatar Technology

  4. Different medicines and combinations are tested

  5. The medical team receives a detailed scientific report

You remain fully under the care of your physician at all times. Our role is to support — with care, integrity, and respect.

Flowchart illustrating a 3D glioblastoma platform. It shows high-throughput starPEG-GAG 3D tumor cultures, followed by patient-specific 3D tumor cultures, then individual and combinatorial drug screening. Results include phenotypic, molecular, and efficacy readouts, leading to patient-specific drug responses and guidance on personalized therapeutic strategies, with timelines of 7 days.

For clinicians and researchers

  • Defined microenvironment

  • Automation-compatible workflows

  • Multiplexed imaging and morphology metrics

  • Option for transcriptomic/proteomic or epigenomic response profiling

  • Decision-relevant insights within clinically-relevant timelines

  • Direct collaboration with treating centers

Our 3D patient-derived glioblastoma platform is built on starPEG–glycosaminoglycan hydrogels that recreate brain-like extracellular cues, enabling high-throughput functional drug testing and drug-response profiling in a 384-well format with high-content omics and phenotypic readouts.

Diagram showing a high-throughput screening system for patient-derived 3D glioblastoma models, including primary patient cells, a liquid handling system, 384-well plates with hydrogel components, and an imaging process for quantification and comparison of drug responses with 3D graphics of sample images and analysis results.

READ THE ORIGINAL PUBLICATION

Kaur Trautman R, Dennison N, McCortney K, Klier S, Cosacak MI, Werner C, Akyoldas G, Horbinski CM, Freudenberg U, Kizil C.

High‐Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening.

Macromolecular Bioscience. 2026. DOI: 10.1002/mabi.202500394

Science you can trust

Rooted in high impact peer-reviewed research and advanced biomaterial science.
Our precision approach begins with understanding each tumor — as it truly behaves.

Our publications on Neuron D 3D technology
Our unique material design

Values and privacy

We vlue compassion, integrity, and partnership.

We care deeply about the people behind every sample. We communicate with honesty. We work together with clinicians — every step of the way.

Privacy is the priority.

Participation requires informed consent. We never ask for patient information or identity. Data are anonymized and securely handled according to GDPR. All results are shared responsibly and only with authorized medical teams. This platform does not diagnose, treat, or cure disease. All medical decisions remain with the treating physician.

About Us

Neuron D GmbH is a biotechnology company based in Dresden, Germany.


We develop advanced 3-dimensional cell culture systems for neuroscience and oncology — translating rigorous science into tools that may help clinicians better understand complex diseases.

We work together with researchers in world-leading academic institutes and hospitals including Columbia University Irving Medical Center, Nortwestern Feinberg School of Medicine, Leibniz Institute for Polymer Research and others.

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Let's start with a conversation

We are happy to offer an initial meeting to discuss your needs and how we may be able to help. We also provide customized testing solutions and collaborative study designs for clinical partners.

  • Patients and families: you may write to us directly, ideally involving your doctor.

  • Clinicians and researchers: we welcome collaboration inquiries or information requests.